Determination of paroxetine levels in human plasma using gas chromatography with electron-capture detection

Authors
Lai, CT Gordon, ES Kennedy, SH Bateson, AN Coutts, RT Baker, GB
Citation
Ct. Lai et al., Determination of paroxetine levels in human plasma using gas chromatography with electron-capture detection, J CHROMAT B, 749(2), 2000, pp. 275-279
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF CHROMATOGRAPHY B
ISSN journal
13872273 → ACNP
Volume
749
Issue
2
Year of publication
2000
Pages
275 - 279
Database
ISI
SICI code
1387-2273(200012)749:2<275:DOPLIH>2.0.ZU;2-J
Abstract
A simple, rapid and sensitive procedure using gas chromatography with elect ron-capture detection to measure paroxetine levels in human plasma has been developed. The analyte was extracted from plasma with ethyl acetate after basification of the plasma and then derivatized with heptafluorobutyric anh ydride before gas chromatographic separation. The calibration curves were l inear, with typical r(2) values >0.99. The assay was highly reproducible an d gave peaks with excellent chromatographic properties. (C) 2000 Elsevier S cience B.V. All rights reserved.