L. Demers et al., Review of outcome measurement instruments in Alzheimer's disease drug trials: Psychometric properties of functional and quality of life scales, J GER PSY N, 13(4), 2000, pp. 170-180
The psychometric properties of functional and quality of life outcome measu
res that were used for the purpose of showing changes in antidementia drug
trials for Alzheimer's disease are described and critiqued. The seven funct
ional scales reviewed for reliability, validity, and responsiveness to chan
ge included the Geriatric Evaluation by Relative's Rating Instrument, the P
hysical Self-Maintenance Scale, the Instrumental Activities of Daily Living
, the Blessed Dementia Scale, Part 1 and its revised version, the Interview
for Deterioration in Daily Living with Dementia, the Unified Activities of
Daily Living, and the Dependence Scale. The Progressive Deterioration Scal
e and Quality of Life Assessment were classified as quality of life scales.
The majority of the scales were found to exhibit serious limitations, such
as incomplete reliability and validity assessment for the intended uses. T
he most pervasive problem was a lack of data on responsiveness to change. I
t is recommended that further research be conducted to develop new tools or
enhance existing measures for the assessment of both quality of life and f
unctional ability.