Samarium iodide mediated methylation: An alternative to Grignard labeling

Authors
Landvatter, SW
Citation
Sw. Landvatter, Samarium iodide mediated methylation: An alternative to Grignard labeling, J LABEL C R, 43(14), 2000, pp. 1321-1326
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
43
Issue
14
Year of publication
2000
Pages
1321 - 1326
Database
ISI
SICI code
0362-4803(200012)43:14<1321:SIMMAA>2.0.ZU;2-I
Abstract
Samarium iodide in THF/HMPA has been used to methylate various aldehydes an d ketones in moderate to good yield. Reaction is complete within two minute s. Labeling using methyl-[C-14] iodide has been successful and is thus an a lternative to labeling via a methyl Grignard derived from methyl-[C-14] iod ide.