Synthesis of a C-11-labelled prostaglandin F-2 alpha analogue using an improved method for Stille reactions with [C-11]methyl iodide

17-(3-[C-11]methylphenyl)-18,19,20-trinor-PGF(2 alpha) isopropyl ester (2) under bar was synthesised using an improved method for cross-coupling react ions with [C-11]methyl iodide. The decay-corrected radiochemical yield of ( 2) under bar was 34 % based on [C-11]methyl iodide in a synthesis time of 3 0 min from end of radionuclide production. The specific radioactivity was a pproximately 100 GBq/mu mol and the radiochemical purity was higher than 95 % as determined by analytical LC. In a typical experiment 1.3 GBq of (2) u nder bar was obtained from 11 GBq of [C-11]methyl iodide.