Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis

Authors
Bringmann, G Hamm, A Gunther, C Michel, M Brun, R Mudogo, V
Citation
G. Bringmann et al., Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis, J NAT PROD, 63(11), 2000, pp. 1465-1470
Citations number
41
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
63
Issue
11
Year of publication
2000
Pages
1465 - 1470
Database
ISI
SICI code
0163-3864(200011)63:11<1465:AAABTN>2.0.ZU;2-N
Abstract
Two new 5,8'-coupled naphthylisoquinoline alkaloids, ancistroealaines A (1) and B (2), eleutherolic acid (3), and two naphthoic acids, ancistronaphtho ic acid A (4) and B (5), have been isolated from Ancistrocladus ealaensis. Their structures were determined by spectroscopic, chemical, and chiroptica l methods. Ancistroealaine,A (1) exhibited activity against Leishmania dono vani and Trypanosoma cruzi in vitro.