Metabolites of Colletotrichum gloesporioides, an endophytic fungus in Artemisia mongolica

A new antimicrobial metabolite, named colletotric acid (1), was isolated fr om a liquid culture of Colletotrichum gloegsporioides, an endophytic fungus colonized inside the stem of Artemisia mongolica. The structure was determ ined using spectroscopic methods (EIMS and FABMS, H-1 and C-13 NMR, H-1-H-1 COSY, HMBC, and HMQC). Compound 1 inhibited the growth of Bacillus subtili s, Staphylococcus aureus, and Sarcina lutea with minimal: inhibitory concen trations (MICs) of 25 50, and 50 mug/mL, respectively, and the crop pathoge nic fungus Helminthosporium sativum (MIC: 50 mug/mL).