Simultaneous estimation of phenylpropanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrups by LC

Authors
Vasudevan, M Ravisankar, S Sathiyanarayanan, A Chandan, RS
Citation
M. Vasudevan et al., Simultaneous estimation of phenylpropanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrups by LC, J PHARM B, 24(1), 2000, pp. 25-31
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN journal
07317085 → ACNP
Volume
24
Issue
1
Year of publication
2000
Pages
25 - 31
Database
ISI
SICI code
0731-7085(200012)24:1<25:SEOPHG>2.0.ZU;2-2
Abstract
A simple, precise and accurate HPLC method was developed for the simultaneo us estimation of phenylpropanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrup. The method was carried out on a Shimpak(R) C-8 column with a mobile phase consisting of acetonitrile-triethylamine (pH adjusted to 3.5 using orthophosphoric acid; 0.5%), (35.65, v/v) at a flow rate of 1.2 mi mi n(-1). Detection was carried out at 210 nm. Diphenhydramine was used as int ernal standard. The validation of the method was also carried out. (C) 2000 Elsevier Science B.V. All rights reserved.