A CONVENIENT SYNTHESIS OF DIFLUOROMETHYL-SUBSTITUTED PYRIDINES

Authors
KATSUYAMA I FUNABIKI K MATSUI M MURAMATSU H SHIBATA K
Citation
I. Katsuyama et al., A CONVENIENT SYNTHESIS OF DIFLUOROMETHYL-SUBSTITUTED PYRIDINES, Synlett, (5), 1997, pp. 591
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
5
Year of publication
1997
Database
ISI
SICI code
0936-5214(1997):5<591:ACSODP>2.0.ZU;2-X
Abstract
The treatment of alpha-alkoxycarbonyl-alpha,beta-unsaturated trifluoro methyl ketones 1 with beta-aminocrotonates 2 affords 2-methyl-6-triflu oromethyl-1,4-dihydropyridines 3, which undergo dehydrofluorination us ing DBU/piperazine, giving moderate to high yields of 2-difluoromethyl -6-methylpyridines 4.