Premature ejaculation treated by local penile anaesthesia in an uncontrolled clinical replication study

The efficacy of local penile anaesthesia in the treatment of premature or r apid ejaculation (PE),was tested Fifteen men with PE (no comorbidity) parti cipated. Subjects applied 2.5 g prilocaine/lidocaine cream to the penis, pu t on a condom, waited 10 min, removed the condom, wiped off the cream and s tarted sexual activity. Various sexual data were collected through postal q uestionnaires. There was a significant (p = 0.003) prolongation in the esti mated time between penile intromission and ejaculation from about 2 mins wi thout the cream to 8 mins with the cream. The sense of control over ejacula tion had also increased (p = 0.005). Men reported a significant (p = 0.005) increase in the occurrence of their partner's orgasm during intercourse. U npleasant effects were numbness of the penis and less than full erection, w hich rarely impeded intromission and ejaculation. Prilocaine/lidocaine crea m applied to the penis is an effective treatment for men with PE. It is rec ommended to advise patients to titrate their own optimal effective amount o f cream, usually less than 2.5 g. When anaesthesia of the glans penis suffi ces, the foreskin, if present, may obviate the use of a condom to allow the active substances to penetrate the skin.