G. Ramakrishna et al., Metastatic non-small cell lung carcinoma with involvement of extremity musculature: Case report and review of the literature, MAYO CLIN P, 75(12), 2000, pp. 1333-1337
Citations number
44
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Hematogenous dissemination of non-small cell lung carcinoma (NSCLC) metasta
tic to skeletal musculature in the absence of osseous involvement is an inf
requent occurrence. We retrospectively reviewed our institution's indexed d
atabase for patients evaluated from 1975 through 1997 who were diagnosed as
having skeletal musculature metastases from NSCLC, Eight men and 2 women w
ere identified (age range, 51-80 years at time of metastases), Four primary
adenocarcinomas, 4 primary lung squamous cell carcinomas (SCCs), and 2 poo
rly differentiated primary NSCLCs were identified. Approximate tumor sizes
ranged from 10 cm(3) to 288 cm(3). External-beam radiation therapy was used
in 7 of 10 cases; complete surgical excision was performed in 3 cases. Pat
ients with known neoplasm who have extremity pain and negative findings on
bone scan should be evaluated for soft tissue tumor involvement because suc
h findings significantly affect clinical management. One case of lung SCC m
etastatic to the quadratus femoris muscle in a 63-year-old man is discussed
in detail.