Fringelite D, a model of the protist photosensory pigments of the stentorin and blepharismin types: The hypericin and fringelite D photosensitized destruction of bilirubin

Using the hypericin and fringelite D photosensitized destruction of bilirub in together with fluorescence spectroscopy it was found that in contrast to fringelite D hypericin behaves as an effective photodynamic agent producin g mainly singlet oxygen. This makes fringelite D and concomitantly the rela ted stentorin and blepharismin pigments better suited for the photosensory transduction chain where, as shown recently, an initial proton expulsion re action plays the fundamental role. Thus, in organisms using these photosens ory pigments the production of deleterious oxygen species becomes diminishe d as compared to hypericin. In addition it was found that complexation with albumin further inhibits bilirubin destruction.