Microwave activated solid support synthesis of new antibacterial quinolones

A novel synthesis of 6-fluoro-7-(5-aryl-1,3,4-thiadliazol/oxadiazol-2-yl-su lfanyl)-4-quinolone-3-carboxylic acids from 7-chloro-6-fluoro-4-quinorone-3 -carboxylic acid and 5-substituted 1,3,4-thiadiazoles/oxadiazoles on basic alumina under microwave activation is described. All compounds were screene d for their in vitro antibacterial activity against B. lichenformis, 2689, K. aerogens 2281, S. typhimurium 2501, E. herbicola 2491, and P. vulgaris 2 027 and found to possess activities comparable to that of the standard drug norfloxacin.