MIXED POLYMER NETWORKS IN THE DIRECT ANALYSIS OF PHARMACEUTICALS IN URINE BY CAPILLARY ELECTROPHORESIS

Two-component polymer mixtures of polyethylene oxide-polydextran have been investigated as unique separation media for capillary electrophor esis. The effects of concentration of the individual polymers and thei r mixtures on the electroosmotic velocity and electrophoretic mobility of small pharmaceutical compounds were investigated. The molecular ma sses of polymers, buffer concentrations and percentages of organic sol vents and cyclodextrins were varied to explore their effects on the se paration process. The plate height against field strength curves were also generated for a better understanding of the kinetic processes inv olved. The two-component polymer mixtures were found as stable and sel ective media for the analysis of an anti-ulcer drug famotidine directl y in untreated urine.