M. Salami et Y. Fathollahi, Do Ca2+ channels share NMDA receptors in plasticity of synaptic transmission in the rat visual cortex?, NEUROREPORT, 11(17), 2000, pp. 3887-3891
We examined the involvement of Ca2+ channels in LTP of responses in rat vis
ual cortex slices; Stimulating layer IV, field potentials including EPSP1 a
nd EPSP2 from layer II/III were recorded. L-type Ca2+ channel blocker nifed
ipine did not have a considerable effect on LTP of the responses. T-type Ca
2+ channel blocker Ni2+ decreased potentiation of EPSP1 and almost blocked
that of EPSP2. Effect of visual experience on the function of the channels
is also considered. These results indicate that T-type Ca2+ channels play a
real role in stable LTP of EPSP2. Also the function of the channels was al
most the same in dark and light reared visual cortices. NeuroReport 11:3887
-3891 (C) 2000 Lippincott Williams & Wilkins.