Acute marijuana effects on rCBF and cognition: a PET study

Citation
Ds. O'Leary et al., Acute marijuana effects on rCBF and cognition: a PET study, NEUROREPORT, 11(17), 2000, pp. 3835-3841
Citations number
17
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
09594965 → ACNP
Volume
11
Issue
17
Year of publication
2000
Pages
3835 - 3841
Database
ISI
SICI code
0959-4965(20001127)11:17<3835:AMEORA>2.0.ZU;2-P
Abstract
The effects of smoking marijuana on cognition and brain function were asses sed with PET using (H2O)-O-15. Regional cerebral blood flow (rCBF) was meas ured in five recreational users before and after smoking a marijuana cigare tte, as they repeatedly performed an auditory attention task. Blood flow in creased following smoking in a number of paralimbic brain regions (e.g. orb ital frontal lobes, insula, temporal poles) and in anterior cingulate and c erebellum Large reductions in rCBF were observed in temporal lobe regions t hat are sensitive to auditory attention effects. Brain regions showing incr eased rCBF may mediate the intoxicating and mood-related effects of smoking marijuana, whereas reduction of task-related rCBF in temporal lobe cortice s may account for the impaired cognitive functions associated with acute in toxication. NeuroReport 11:3835-3841 (C) 2000 Lippincott Williams & Wilkins .