Synthesis of 6-acetamido-5-amino- and-5-guanidino-3,4-dehydro-N-(2-ethylbutyryl) 3-piperidinecarboxylic acids related to zanamivir and oseltamivir, inhibitors of influenza virus neuraminidases

Authors
Shitara, E Nishimura, Y Nerome, K Hiramoto, Y Takeuchi, T
Citation
E. Shitara et al., Synthesis of 6-acetamido-5-amino- and-5-guanidino-3,4-dehydro-N-(2-ethylbutyryl) 3-piperidinecarboxylic acids related to zanamivir and oseltamivir, inhibitors of influenza virus neuraminidases, ORG LETT, 2(24), 2000, pp. 3837-3840
Citations number
38
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
24
Year of publication
2000
Pages
3837 - 3840
Database
ISI
SICI code
1523-7060(20001130)2:24<3837:SO6A>2.0.ZU;2-G
Abstract
[GRAPHICS] 6-Acetamido-5-amino- and -5-guanidino-3,4-dehydro-N-(2-ethylbutyryl)-3-pipe ridinecarboxylic acids (8 end 9) have been synthesized starting from natura l siastatin a, a bacterial neuraminidase inhibitor isolated from Streptomyc es culture in a stereospecific fashion. These compounds are related to zana mivir and oseltamivir, inhibitors of influenza virus neuraminidases.