Hereditary multiple exostoses and acute myeloid leukemia: An unusual association

Authors
Gozdasoglu, S Uysal, Z Kurekci, AE Akarsu, S Ertem, M Fitoz, S Ikinciogullaril, A Cin, S
Citation
S. Gozdasoglu et al., Hereditary multiple exostoses and acute myeloid leukemia: An unusual association, PED HEM ONC, 17(8), 2000, pp. 707-711
Citations number
10
Categorie Soggetti
Pediatrics
Journal title
PEDIATRIC HEMATOLOGY AND ONCOLOGY
ISSN journal
08880018 → ACNP
Volume
17
Issue
8
Year of publication
2000
Pages
707 - 711
Database
ISI
SICI code
0888-0018(200012)17:8<707:HMEAAM>2.0.ZU;2-D
Abstract
Hereditary multiple exostoses (HME) is an autosomal dominant disorder chara cterized by the presence of multiple exostoses. Three genetic loci have bee n identified, of which two (EXT1 and EXT2) have tumor suppressor activity. HME greatly increases the risk to develop sarcoma in the dysplastic tissue. The authors report an 8-year-old girl with HME, who developed acute myelob lastic leukemia.