SERUM LEVELS OF IGG ANTIBODIES AGAINST TAMM-HORSFALL PROTEIN AND URINARY-EXCRETION OF NAG AND ALPHA-1-MICROGLOBULIN AS POSSIBLE MARKERS FORTUBULAR DAMAGE IN PATIENTS WITH A CONTINENT ILEAL RESERVOIR FOR URINARY-DIVERSION
M. Campanello et al., SERUM LEVELS OF IGG ANTIBODIES AGAINST TAMM-HORSFALL PROTEIN AND URINARY-EXCRETION OF NAG AND ALPHA-1-MICROGLOBULIN AS POSSIBLE MARKERS FORTUBULAR DAMAGE IN PATIENTS WITH A CONTINENT ILEAL RESERVOIR FOR URINARY-DIVERSION, Scandinavian journal of urology and nephrology, 31(3), 1997, pp. 237-243
Serum IgG antibodies against Tamm-Horsfall protein and urinary excreti
on of NAG and alpha-1-microglobulin were measured in 26 patients with
a Kock reservoir for continent urinary diversion or orthotopic bladder
reconstruction in order to detect any signs of tubular damage. None o
f these markers for tubular damage was correlated to the postoperative
observation time ranging between 2 and 16 years. No correlation was f
ound between these markers and signs of renal scarring or upper urinar
y tract dilatation as judged from urographies. A positive correlation
was demonstrated between NAG excretion and antibodies against Tamm-Hor
sfall protein. The annual reduction in GFR was increased in patients w
ith elevated alpha-1-microglobulin excretion but not in patients with
elevated titres of antibodies against Tamm-Horsfall protein or increas
ed NAG excretion. Patients with previous or present reflux nipple prob
lems had elevated excretion of alpha-l-microglobulin. Regular determin
ations of alpha-l-microglobulin excretion appear to be of value in the
follow-up of these patients.