Plasma superoxide dismutase activity and malondialdehyde level correlate with the extent of acute appendicitis

Although the mechanism of acute appendicitis (AA) is partly understood, the progression following the onset of inflammation has not yet been clarified . To determine oxidative activities in the plasma of patients with AA, supe roxide dismutase (SOD) activities and malondialdehyde (MDA) levels were mea sured in samples from 31 patients diagnosed as having AA and 10 otherwise h ealthy children with inguinal pathologies. The patients with AA were divide d into three subgroups: acute focal (AFA) (n = 8), acute suppurative (ASA) (n = 9), and acute perforated appendicitis (APA) (n = 14), according to the intraoperative findings and histopathologic examination.. SOD and MDA were compared statistically between these subgroups and between them and the co ntrol group. Additionally, mean leukocyte counts of each group were determi ned and the differences between the groups were evaluated. Both SOD and MDA were significantly higher in the ASA and APA groups compared to controls a nd AFA group. The mean leukocyte numbers of the ASA and APA groups were sig nificantly higher compared to the AFA group. Based to these results, it may be speculated that oxygen free radicals (OFR) may play an important role i n the extent of AA. To prevent the hazardous effects of OFR, the organism m ay increase SOD and other antioxidant enzyme levels and/or activities.