Studies on the conformations of O-uridine-5 '-yl O-alkyl N-phosphoryl serine methyl esters by nuclear magnetic resonance (NMR) and circular dichroism(CD)

Authors
Feng, YP Han, B Tan, B Zhao, YF
Citation
Yp. Feng et al., Studies on the conformations of O-uridine-5 '-yl O-alkyl N-phosphoryl serine methyl esters by nuclear magnetic resonance (NMR) and circular dichroism(CD), PHOSPHOR SU, 164, 2000, pp. 173-180
Citations number
9
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
ISSN journal
10426507 → ACNP
Volume
164
Year of publication
2000
Pages
173 - 180
Database
ISI
SICI code
1042-6507(2000)164:<173:SOTCOO>2.0.ZU;2-9
Abstract
The conformations of O-uridine-5'-yl O-alkyl N-phosphoryl serine methyl est ers (1) and (2) have been investigated by nuclear magnetic resonance (NMR) and circular dichroism (CD) techniques. Nuclear Overhauser effect (NOE) mea surements and CD studies revealed that the glycosyl bonds in both compounds favor the syn orientation. The stereosensitive P-31-C-13 coupling constant s were also measured and used for the analysis of the trans and gauche conf ormations. The three-dimensional structural characteristics of compounds (1 ) and (2) were discussed.