Synthesis of pyridazothienothiazine and pyrimidothienopyridazines

Authors
Radwan, SM El-Dean, AMK
Citation
Sm. Radwan et Amk. El-dean, Synthesis of pyridazothienothiazine and pyrimidothienopyridazines, PHOSPHOR SU, 164, 2000, pp. 299-313
Citations number
17
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
ISSN journal
10426507 → ACNP
Volume
164
Year of publication
2000
Pages
299 - 313
Database
ISI
SICI code
1042-6507(2000)164:<299:SOPAP>2.0.ZU;2-Z
Abstract
3-amino-4,5-diphenylthieno[2, 3-c]pyridazine-2-arylcarboxamide 2 underwent cyclization with triethyl orthoformate and with nitrous acid to give the py rimidothienopyridazines 3a-c, 4b respectively. 3-amino-4,5-diphenylthieno [ 2,3-c] pyridazine-2-carbohydrazide 6 reacted with aromatic aldehydes to giv e;the corresponding carbohydrazones 7a-c. Compound 7 reacts with triethyl o rthoformate, acetic anhydride or with CS2/pyridine to produce pyrimidothien opyridazines 8,9 and pyridazothienothiazine 11.