SYNTHESIS OF NOVEL TETRAPEPTIDES AS POTENTIAL ACE-INHIBITORS

Authors
TANDON R SINGH MP HAQ W DIKSHIT M PATNAIK GK DHAR MM
Citation
R. Tandon et al., SYNTHESIS OF NOVEL TETRAPEPTIDES AS POTENTIAL ACE-INHIBITORS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 36(5), 1997, pp. 386-390
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
36
Issue
5
Year of publication
1997
Pages
386 - 390
Database
ISI
SICI code
0376-4699(1997)36:5<386:SONTAP>2.0.ZU;2-F
Abstract
Pepsin hydrolysis of wheat gluten yields a tetrapeptide, Leu-Gln-Pro-A rg (1) which exhibits potent ACE inhibitory activity. Analogues (2-7) of this peptide have been synthesized and examined for ACE inhibitory activity in vitro and in vivo. None of the compounds synthesized showe d improved in vivo activity. However, compound 6 has been found to be as active as captopril in in vitro assay.