SYNTHESIS OF DIHETEROARYLMETHANES FROM ACTIVATED NITRILES

Authors
RAM VJ NATH M
Citation
Vj. Ram et M. Nath, SYNTHESIS OF DIHETEROARYLMETHANES FROM ACTIVATED NITRILES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 36(5), 1997, pp. 394-398
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
36
Issue
5
Year of publication
1997
Pages
394 - 398
Database
ISI
SICI code
0376-4699(1997)36:5<394:SODFAN>2.0.ZU;2-Z
Abstract
Novel procedures for the synthesis of diheteroarylmethanes 3-7 have be en developed from the base-catalysed condensation-cyclization reaction s of (indol-3-yl)methylmalononitrile 2 with amidine, dicyandiamide, hy droxylamine, hydrazine and thioglycolic acid separately. The acid cata lysed reaction of 1 and 9 with thiosemicarbazide separately affords 8 and 10. The latter on reaction with phenacyl bromide yield 11. Base-ca talysed reaction of 9 with dicyandiamide gives symmetrical triazine 14 .