We study a model for the denaturation transition of DNA in which the molecu
les are considered as being composed of a sequence of alternating bound seg
ments and denaturated loops. We take into account the excluded-volume inter
actions between denaturated loops and the rest of the chain by exploiting r
ecent results on scaling properties of polymer networks of arbitrary topolo
gy. The phase transition is found to be first order in d = 2 dimensions and
above, in agreement with experiments and at variance with previous theoret
ical results, in which only excluded-volume interactions within denaturated
loops were taken into account. Our results agree with recent numerical sim
ulations.