N-methylsansalvamide, a cytotoxic cyclic depsipeptide from a marine fungusof the genus Fusarium

Authors
Cueto, M Jensen, PR Fenical, W
Citation
M. Cueto et al., N-methylsansalvamide, a cytotoxic cyclic depsipeptide from a marine fungusof the genus Fusarium, PHYTOCHEM, 55(3), 2000, pp. 223-226
Citations number
7
Categorie Soggetti
Agricultural Chemistry","Animal & Plant Sciences
Journal title
PHYTOCHEMISTRY
ISSN journal
00319422 → ACNP
Volume
55
Issue
3
Year of publication
2000
Pages
223 - 226
Database
ISI
SICI code
0031-9422(200010)55:3<223:NACCDF>2.0.ZU;2-9
Abstract
N-Methylsansalvamide (1), a new cyclic depsipeptide. was isolated from extr acts of a cultured marine fungus, strain CNL-619, identified as a member of the genus Fusarium. N-Methylsansalvamide exhibits weak in vitro cytotoxici ty in the NCI human tumor cell line screen (GI(50) 8.3 muM). The structure of 1 was determined by combined spectral and chemical methods. (C) 2000 Els evier Science Ltd. All rights reserved.