Isolated polydactyly: prenatal diagnosis and perinatal outcome

Our objective was to determine the clinical significance of isolated polyda ctyly identified on prenatal sonogram. All patients with sonographically de tected isolated polydactyly scanned over an Ii-year period were identified from our database. All patients underwent detailed surveys, and follow-up w as obtained by review of the medical records and telephone conversations wi th parents and referring physicians. Thirteen patients with isolated polyda ctyly were identified. Follow-up was available in 12 patients. Indications for referral included advanced maternal age (2), second-opinion polydactyly (4), family history of polydactyly (1), uncertain dates (5), and growth (1 ). The gestational ages at the times of sonographic diagnosis ranged from 1 7.5 to 34 weeks with all but one case being identified before 23 weeks. Pre natal identification included polydactyly of the upper limb (8), lower limb (4), and both upper and lower limbs (1). Postaxial polydactyly was seen in 12 patients and preaxial in one. Polydactyly was confirmed in all 12 cases in which follow-up was available. Karyotypes were normal ill all five fetu ses in which amniocentesis was performed. Ten of 12 fetuses were born alive , one died in utero at 34 weeks as a complication of severe pre-eclampsia a nd one died at term as a result of a cord accident. No surviving neonate ha d any other identifiable malformation or suspected karyotypic abnormality. In conclusion isolated polydactyly identified by prenatal sonography is ass ociated with good perinatal outcome. Copyright (C) 2000 John Wiley & Sons, Ltd.