Effects of small dose of brotizolam on P300

Nine healthy men (mean age, 22.2 years) participated in two experimental se ssions cross-overed randomly in a double blind manner; one with a placebo a nd the other with 0.125 mg of brotizolam (BTZ) administered in the morning. Resting electroencephalogram and event-related potential under oddball par adigm was recorded before and 1, 2, 4, 6 and 8h after the administration. M ean 30-msec bin amplitude from 240 msec to 450 msec after the stimulus was compared between placebo and drug sessions in order to observe P300. Brotiz olam reduced the amplitude of P300 at 6 h after administration. It was note d that the effects of BTZ were most marked at Fz.