Diagnosis of prostatic intraepithelial neoplasia - Prostate Working Group 1 Consensus report

High-grade prostatic intraepithelial neoplasia (PIN) is the most likely pre cursor of prostatic carcinoma. PIN has a high predictive value as a marker for carcinoma, and its identification in biopsy specimens warrants repeat b iopsy for concurrent or subsequent carcinoma. The only methods of detection are biopsy and transurethral resection; PIN does not significantly elevate serum PSA concentration or its derivatives, nor does it induce a palpable mass, and cannot be detected by ultrasound. Androgen deprivation therapy de creases the prevalence and extent of PIN, suggesting that this form of trea tment may play a role in chemoprevention. Radiation therapy is also associa ted with a decreased incidence of PIN.