Diagnosis of cerebrospinal fluid leakage at the skull base

There are still several problems surrounding the diagnosis of cerebrospinal fluid leak. Currently the method of choice for cerebrospinal fluid detecti on is qualitative determination of beta -2-transferrin. Faster and more eff icient: methods (beta -trace) are under clinical investigation. The major p roblem is localisation of the site of leakage. Combination of several radio logical methods increases the rate of correct diagnosis. In surgery the use of intrathecal sodium-fluorescein improves visualisation of the site of le akage and thus increases the chances of secure and stable closure of the ce rebrospinal fluid fistula.