Recurrent Clostridium difficile enterocolitis

Pseudomembranous enterocolitis generally occurs after antibiotic treatment. The standard treatment is oral metronidazol or vancomycin. Nevertheless, r elapses of Clostridium difficile enterocolitis are observed in 10-25% of ca ses. Factors associated with recurrences include endogenous reinfection by spore formation, selective IgG(1) or IgA deficiency or infection with mutat ed strains of Clostridium difficile. Recurrent Clostridium difficile entero colitis may be treated with repeat oral vancomycin combined with Sacchoromy ces boulardii, with intravenous immunoglobulin for severe colitis.