5,6-CIS-PENEMS - BROAD-SPECTRUM ANTI-METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS BETA-LACTAM ANTIBIOTICS

5,6-cis-Penem derivatives have been synthesized and evaluated as anti- MRSA antibiotics. The cis-penems 5 and 6 showed potent activities agai nst not only MRSA but also a wide variety of bacteria including beta-l actamase-producing microorganisms. These compounds were designed to ha ve high affinity to the penicillin-binding protein 2a of MRSA and to f orm stable acyl intermediates with beta-lactamases by blocking the dea cylating water molecule.