Excretion patterns of mucosally delivered antibodies to p23 in Cryptosporidium parvum infected calves

Fecal samples obtained at intervals from six calves with acute cryptosporid iosis contained antibodies of multiple isotypes to p23. IgM-, IgA-, and IgG (1)-isotype anti-p23 appeared before IgG(2)-isotype antibodies. All anti-p2 3 antibodies had declined by 2 months after infection. One calf that failed to shed oocysts following initial exposure developed IgG(1)-isotype anti-p 23 antibodies. One calf that died following exposure to Cryptosporidium par vum oocysts lacked detectable anti-p23 antibodies. Re-inoculation with C, p arvum resulted in a brief, marked recall response to p23, (C) 2000 Elsevier Science B.V. All rights reserved.