Sensitivity to interferon-alpha and interferon-stimulated gene factor 3 binding activity in human chronic myelogenous leukemia cell line KT-1

Authors
Yamauchi, H Sakai, I Narumi, H Soga, S Fujita, S
Citation
H. Yamauchi et al., Sensitivity to interferon-alpha and interferon-stimulated gene factor 3 binding activity in human chronic myelogenous leukemia cell line KT-1, ACT HAEMAT, 104(1), 2000, pp. 1-9
Citations number
39
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
ACTA HAEMATOLOGICA
ISSN journal
00015792 → ACNP
Volume
104
Issue
1
Year of publication
2000
Pages
1 - 9
Database
ISI
SICI code
0001-5792(2000)104:1<1:STIAIG>2.0.ZU;2-5
Abstract
The mechanism of responsiveness of chronic myelogenous leukemia (CML) cells to interferon (IFN)-alpha was examined by using two subclones of CML cell line KT-1 which exhibited significantly different sensitivities to the anti proliferative and apoptosis-inducing effects of IFN-alpha, IFN-stimulated g ene factor 3 (ISGF3) formation by IFN-alpha was reduced in the IFN-alpha -r esistant subclone compared to the IFN-alpha -sensitive subclone. We conclud e that the level of ISGF3 formation is responsible for the difference in IF N-alpha responses between these subclones. Copyright (C) 2000 S. Karger AG, Basel.