Granulocytic sarcoma with breast and skin presentation: A report of a casesuccessfully treated by local radiation and systemic chemotherapy

Granulocytic sarcoma (GS) is a rare extramedullary tumor composed of immatu re myeloid cells. It is usually associated with leukemia or other myeloprol iferative disorders, but can also occur without overt hematologic disease, i.e. in patients with a normal bone marrow and no history of acute myelogen ous leukemia. This primary extramedullary lesion may indeed represent a dia gnostic and therapeutic dilemma for both the hematopathologist and oncologi st. We describe a case of GS diagnosed in a nonleukemic patient and review the literature regarding the pathologic features and treatment of this cond ition. Copyright (C) 2000 S. Karger AG, Basel.