CD3+, CD4-, CD8-, TCR alpha beta-, TCR gamma delta+ granular lymphocyte proliferative disorder without lymphocytosis and clinical symptoms

Granular lymphocyte-proliferative disorder is characterized by a proliferat ion of large granular lymphocytes (LGLs). It is often associated with neutr openia, rheumatoid arthritis (RA), and pure red cell aplasia,(PRCA). Phenot ypic analysis has demonstrated that in most cases, the LGLs show a clonal r earrangement of the TCR alpha beta rearrangement. We are reporting a patien t with TCR gamma delta LGL proliferation without clinical findings and lymp hocytosis, The patient showed an expansion of the CD3+, CD16+, CD56+, and C D57+ LGL populations which involved coexpression of TCR gamma delta with TC R J gamma and J delta1 gene rearrangement. Autoimmune manifestations, inclu ding RA and PRCA, have not appeared and the results of laboratory examinati ons have not changed for 1 year after the diagnosis. Copyright (C) 2000 S. Karger AG, Basel.