Altered frequency of a promoter polymorphism of the kinin B-2 receptor gene in hypertensive African-Americans

Citation
Jv. Gainer et al., Altered frequency of a promoter polymorphism of the kinin B-2 receptor gene in hypertensive African-Americans, AM J HYPERT, 13(12), 2000, pp. 1268-1273
Citations number
50
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
AMERICAN JOURNAL OF HYPERTENSION
ISSN journal
08957061 → ACNP
Volume
13
Issue
12
Year of publication
2000
Pages
1268 - 1273
Database
ISI
SICI code
0895-7061(200012)13:12<1268:AFOAPP>2.0.ZU;2-9
Abstract
Components of the kallikrein kinin system have been associated with the pat hophysiology of hypertension in animal and human studies. In this study, we examined the distribution of four different polymorphisms of the kinin B-1 and B-2 receptor genes in a population of 120 normotensive and 77 hyperten sive African-Americans. Allelic frequencies for three of the four polymorph isms were significantly different from those previously reported in Caucasi an populations. Among the polymorphisms analyzed a potentially functionally significant polymorphism in the core promoter of the kinin B-2 receptor (C -58-->T transition) displayed an increased prevalence of the C-58 allele in the hypertensive patients as compared with the controls (0.75 v 0.65 P =.0 09). Thus, this B-2 receptor promoter polymorphism may represent a suscepti bility marker for essential hypertension in African-Americans. Am J Hyperte ns 2000;13:1268-1273 (C) 2000 American Journal of Hypertension, Ltd.