Effect of administration of nonsteroidal anti-inflammatory drugs before surgery on renal function in clinically normal dogs

Objectives-To investigate renal function in clinically normal dogs undergoi ng general anesthesia for ovariohysterectomies that received nonsteriodal a ntiinflammatory drugs (NSAID) before surgery. Animals-40 clinically normal dogs. Procedure-After induction of anesthesia, dogs were given an analgesic. Rena l function was assessed before surgery and 24 and 48 hours after surgery by means of serum urea and creatinine concentrations, fractional clearance of sodium (FCNa), urine gamma -glutamyltransferase [GGT) and alkaline phospha tase (ALP) activities, and urine analysis. Ten dogs in each of 4 groups rec eived ketorolac tromethamine (0.5 mg/kg of body weight), ketoprofen (1 mg/k g), carprofen (4 mg/kg), or morphine (0.1 mg/kg; control group). Results-Duration of general anesthesia ranged from 1.75 to 5 hours, with a mean of 3 hours. Two ketorolac- and 2 ketoprofen-treated dogs had transient azotemia. A significant decrease in the FCNa, between before surgery and 2 4 hours after surgery, and between before surgery and 48 hours after surger y, was found in ketoprofen- and carprofen-treated dogs. Ketorolac-, ketopro fen-, and morphine-treated dogs had a decrease in urine specific gravity. T wo ketorolac-1 ketoprofen-, 1 carprofen; and 4 morphine-treated dogs had in creases in renal tubular epithelial cells on urine sediment examination 24 hours after surgery. Conclusions and Clinical Relevance-In clinically normal dogs undergoing gen eral anesthesia and elective surgery, the use of NSAID as analgesics is not contraindicated. Compared with ketorolac or ketoprofen, carprofen had the least effect on renal function and integrity.