Comparative in vitro evaluation of dequalinium B, a new boron carrier for neutron capture therapy (NCT)

A boronated derivative of dequalinium, a delocalized lipophilic cation (DLC ), was synthesized as a potential boron carrier for the selective targeting of mitochondria in malignant versus benign cells for boron neutron capture therapy (BNCT), a binary modality for the treatment of cancer. This agent, designated DEQ-B, was taken lip and retained in vitro in the KB, F98, and C6 tumor cell lines but not in the normal epithelial cell line CVI. DEQ-B w as also less toxic in the latter cell fine at lower exposure concentrations The uptake, retention, and toxicity profiles of DEQ-B ate comparable to th ose of the non-boronated DLCs, dequalinium, MKT 077, RH 123, and tetrapheny lphosphonium chloride. Our results suggest that the synthesis and further e valuation of boronated DLCs as potential delivery agents for BNCT is warran ted.