Radiation induced effect of the vitamins C, E and beta-carotene on sanazole efficiency. A study in vitro

The effect of the vitamins C, E-acetate and beta -carotene on the sanazole (AK-2123) efficiency was investigated in vitro (E. coli bacteria AB 1157) u nder the influence of gamma -rays. The vitamins were applied with sanazole individually or in appropriate mixtures in airfree media as well as in medi a saturated with nitrous oxide (N2O) or ail: The addition of vitamin C led in all cases to a very strong enhancement of the sanazole efficiency, namel y: in airfree media to 2-fold, in the presence of N2O to 1.5-fold and in th e presence of ai, to 2-fold, The influence of vitamin E-acetate and beta -c arotene and matures of them depended on the respective gas rued for saturat ion of the medium. An attempt was made to estimate the role of the reducing (e(aq)(-), H-atoms) and oxidizing radicals (OH, O-2(.)) in respect to the influence of the sanazole activity. The results are of interest for the che moradiation therapy of cancer.