Radiosynthesis of [I-123]beta CIT, a selective ligand for the study of thedopaminergic and serotoninergic systems in human brain

Authors
Carpinelli, A Matarrese, M Moresco, RM Simonelli, P Todde, S Magni, F Kienle, MG Fazio, F
Citation
A. Carpinelli et al., Radiosynthesis of [I-123]beta CIT, a selective ligand for the study of thedopaminergic and serotoninergic systems in human brain, APPL RAD IS, 54(1), 2001, pp. 93-95
Citations number
12
Categorie Soggetti
Multidisciplinary
Journal title
APPLIED RADIATION AND ISOTOPES
ISSN journal
09698043 → ACNP
Volume
54
Issue
1
Year of publication
2001
Pages
93 - 95
Database
ISI
SICI code
0969-8043(200101)54:1<93:RO[CAS>2.0.ZU;2-F
Abstract
The procedure previously reported for the radiosynthesis of [I-123]beta CIT was modified in order to improve both radiochemical yield and purity of be ta CIT (2 beta -carbomethoxy-3 beta (4-iodophenyl) tropane) to be injected for SPECT (Single Photon Emission Computed Tomography) analysis imaging. Th e overall procedure, involving a HPLC purification step, results in quite g ood and reproducible yields of a highly purified tracer. (C) 2000 Elsevier Science Ltd. All rights reserved.