The advanced glaucoma intervention study, 6: Effect of cataract on visual field and visual acuity

Authors
Ederer, F Sullivan, EK Van Veldhuisen, PC Gaasterland, DE Wu, LL Sonty, S Beck, A Schwartz, AL Prum, BE Costarides, A Leef, D Closek, J Banks, J Jackson, S Moore, K Vela, A Brown, RH Lynch, M Gunsby, J Lober, K Marsh, T Stepka, C Montgomery, R Clagett, D Ashburn, F Schacht, K Coyle, E Garland, MK Lauber, S Michelitsch, K Plavnieks, S Vayer, L Burt, E Hundley, M Rae, A Allen, RC Miller, E Sporn, A Fendley, CK Hoyle, LS Weber, PA McKinney, K Moore, D Lauderbaugh, T Baker, ND Kapetansky, F Lehmann, D Black, L Derick, R Gloeckner, B Coleman, K Cassady, M Sharf, LJ Romans, B Satterwhite, Y Simmons, L Vela, MA Harbin, TS Brannon, L Wright, J LaSalle, J Degenhardt, G Bridgman, SA Ozment, RR Hooper, M Goldstein, S Butler, L Perry, M Eckel, A Martin, A Session, C Nummerdor, D Wille, L Cyrlin, MN Dubay, H Fazio, R Corbin, PS Wilensky, JT Lindenmuth, K Hillman, D Carroll, CA Hatton, J Carroll, CA Higginbotham, EJ Scholes, G Uva, R Fiene, J Frohlichstein, D Gates, V Pappas, L Rathbone, D Tadelman, M Hopkins, G Lichter, PR Bergstrom, TJ Moroi, SE Pollack-Rundle, CJ Standardi, C Abt, L Van Heck, T Skuta, GL Higginbotham, EJ Schertzer, RM Wicker, D Michael, B Aaron, D Birk, J Brown, RS Dederian, J Kruscke, L Ziehm-Scott, J Papierniak-Dubiel, R Prum, BE Newman, SA Powell, L Evans, C Barbour, N Shoffstall-Tyler, L Voight, T Nordlund, JR Schott, LJ Fornili, R Chisholm, J Harrell, C Harris, C Murphy, E Schwartz, AL Weiss, H Boeckl, A Tillman, C Boeckl, A Maloney, L Cirone, M Gurley, J Morris, M O'Dea, M Pappas, S Wehrly, S Reed, C Witol, CV Browning, J Carmody, K Driskell, T Harris, E Lopez, P Mercer, R Monks, V Vawter, K Zhao, J Katz, LJ Spaeth, GL Wilson, RP Myers, J Samuel, F Meli, A Kao, S Terebuh, A Beckershoff, CC Shields, MB Shafranov, G Leone, A Grottole, G Miller, E Caprioli, J Tressler, C Roche-Manna, M VanVeldhuisen, PC Dally, LG Blackwell, B Inman, P Raitt, S Lindblad, AS Knoke, JD Sullivan, EK Wu, LL Entler, G Phillips, P Smith, C Bradford, M Denekas, M Wagner, EL Stine, E Tomlin, KL Voss, T Cotch, MF Darby, WW Mowery, RL Goff, F Grimes, C Lynch, G Furberg, CD Connett, JE Daivs, MD Dueker, DK Green, SB Palmberg, PF Cotch, MF Leikin, S Schneiderman, M Hamilton, MP Mowery, RL Schwartz, AL Lindblad, AS Knoke, JD Sullivan, EK Ederer, F Schwartz, AL Kassoff, A Cotch, MF Cyrlin, MN Vela, MA Caprioli, J Higginbotham, EJ Skuta, GL Katz, LJ Weber, PA Allen, RC Wilensky, JT Miller, E Brown, R Prum, B Cyrlin, M Lichter, P Leef, D McKinney, K Reed, C Uva, R Samuel, F Manna, MR Standardi, C Coyle, E Boeckl, A Pollack-Rundle, CJ Carroll, CA Sporn, A Leone, A Mowery, RL Kassoff, A Katz, LJ Leef, D Skuta, GL Standardi, C Samuel, F Lindblad, AS Reed, C Beckershoff, CC Entler, G Wagner, EL
Citation
F. Ederer et al., The advanced glaucoma intervention study, 6: Effect of cataract on visual field and visual acuity, ARCH OPHTH, 118(12), 2000, pp. 1639-1652
Citations number
26
Categorie Soggetti
Optalmology,"da verificare
Journal title
ARCHIVES OF OPHTHALMOLOGY
ISSN journal
00039950 → ACNP
Volume
118
Issue
12
Year of publication
2000
Pages
1639 - 1652
Database
ISI
SICI code
0003-9950(200012)118:12<1639:TAGIS6>2.0.ZU;2-B
Abstract
Objective: To investigate the effect of cataract on visual function and the role of cataract in explaining a race-treatment interaction in outcomes of glaucoma surgery. Methods; The Advanced Glaucoma Intervention Study (AGIS) enrolled 332 black patients (451 eyes) and 249 white patients (325 eyes) with advanced glauco ma. Eyes were randomly assigned to an argon laser trabeculoplasty (ALT)-tra beculectomy-trabeculectomy sequence or a trabeculectomy-ALT-trabeculectomy sequence. From the AGIS experience with cataract surgery during followup, w e estimated the expected change in visual function scores from before catar act surgery to after. cataract surgery. Then, for eyes with cataract not re moved, we used these estimates of expected change to adjust visual function scores for the presumed effects of cataract. in turn, we used the adjusted scores to obtain cataract-adjusted main outcome measures. Main Outcome Measures: Average percent of eyes with decrease of visual fiel d (APDVF) and average percent of eyes with decrease of visual acuity (APDVA ). Results: Within the 2 months before cataract surgery, visual acuity was bet ter ill eyes of white patients than of black patients by an average of appr oximately 2 lines on the visual acuity test chart. Cataract surgery improve d visual acuity and visual field defect scores, with the amounts of improve ment greater when preoperative visual acuity was lower. Adjustments for cat aract brought about the following relative reductions: for APDVF, a relativ e reduction of 5% to 11% in black patients and 9% to 11% in white patients; for APDVA, a relative reduction of 45% to 49% in black patients and 31% to 38%, in white patients; and for the APDVF and APDVA race-treatment interac tions, relative reductions of 25% and 45%, respectively. Conclusions: On average, visual function scores improved after cataract sur gery. The findings of reduced race treatment interactions after adjustment for cataract do not alter our earlier conclusion that the AGIS 7-year resul ts support use of the ALT-trabeculectomy trabeculectomy sequence for black patients and of the trabeculectomy-ALT-trabeculectomy sequence for white pa tients without life-threatening health problems. The choice of treatment sh ould take into account individual patient characteristics and needs.