Deletion and dosage modulation of the eEF1A gene in Podospora anserina: effect on the life cycle

Authors
Silar, P Rossignol, M Haedens, V Derhy, Z Mazabraud, A
Citation
P. Silar et al., Deletion and dosage modulation of the eEF1A gene in Podospora anserina: effect on the life cycle, BIOGERONTOL, 1(1), 2000, pp. 47-54
Citations number
34
Categorie Soggetti
Medical Research General Topics
Journal title
BIOGERONTOLOGY
ISSN journal
13895729 → ACNP
Volume
1
Issue
1
Year of publication
2000
Pages
47 - 54
Database
ISI
SICI code
1389-5729(2000)1:1<47:DADMOT>2.0.ZU;2-F
Abstract
eEF1A is encoded by a unique gene in the filamentous fungus Podospora anser ina. We show here: that (1) this gene is essential for vegetative growth, ( 2) readthrough at UGA stop codon level is positively correlated with eEF1A level, (3) eEF1A level is regulated in P. anserina. (4) Increasing eEF1A ge ne dosage does not modify P. anserina life cycle parameters, especially lon gevity is not changed. These data confirm and extend those previously obtai ned in yeast and Drosophila.