2,4,5-trisubstituted imidazoles: Novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 1

Authors
Sarshar, S Zhang, CZ Moran, EJ Krane, S Rodarte, JC Benbatoul, KD Dixon, R Mjalli, AMM
Citation
S. Sarshar et al., 2,4,5-trisubstituted imidazoles: Novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 1, BIOORG MED, 10(23), 2000, pp. 2599-2601
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
23
Year of publication
2000
Pages
2599 - 2601
Database
ISI
SICI code
0960-894X(200012)10:23<2599:2INNMO>2.0.ZU;2-A
Abstract
N-4,5-Di-(4-dialkylamino)phenyl imidazoles (A) are potent modulators of P-g lycoprotein mediated multidrug resistance. This manuscript describes the di scovery and lead optimization of this novel class of inhibitors. (C) 2000 E lsevier Science Ltd. All rights reserved.