Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex

Authors
Bence, AK Rogers, DT Worthen, DR Fu, M Littleton, JM Crooks, PA
Citation
Ak. Bence et al., Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex, BIOORG MED, 10(23), 2000, pp. 2621-2623
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
23
Year of publication
2000
Pages
2621 - 2623
Database
ISI
SICI code
0960-894X(200012)10:23<2621:AANLAT>2.0.ZU;2-K
Abstract
As part of a drug discovery program using high-throughput radioligand-bindi ng assays, aminoanthraquinones were identified as potential modulators of N -methyl-D-aspartate (NMDA) receptor function. Aminoanthraquinones may repre sent a novel class of polyamine binding site ligands with a unique pharmaco phore and may facilitate the rational design of novel NMDA-receptor modulat ors. (C) 2000 Elsevier Science Ltd. All rights reserved.