Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and Lisinopril microalbuminuria (CALM) study

Objectives To assess and compare the effects of candesartan or lisinopril, or both, on blood pressure and urinary albumin excretion in patients with m icroalbuminuria, hypertension, and type 2 diabetes. Design Prospective, randomised, parallel group, double blind study with fou r week placebo run in period and 12 weeks' monotherapy with candesartan or lisinopril followed by 12 weeks' monotherapy or combination treatment Setting Tertiary hospitals and primary care centres in four countries (37 c entres). Participants 199 patients aged 30-75 years. Interventions Candesartan 16 mp; once daily, lisinopril 20 mg once daily. Main outcome measures Blood pressure and urinary albumin:creatinine ratio. Results At 12 creeks mean (95% confidence interval) reductions in diastolic blood pressure were 9.5 mm Hg (7.7 mm Hg to 11.2 mm Hg, P < 0.002) and 9.7 mm Hg (7.9 mm Hg to 115 mm Hg, P < 0.001), respectively, and in urinary al bumin:creatinine ratio were 30% (15% to 42%, P < 0.001) and 46% (35% to 56% , P < 0.001) for candesartan and lisinopril, respectively. At 24 weeks the mean reduction in diastolic blood pressure with combination treatment (16.3 mm Hg, 13.6 mm Hg to 18.9 mm Hg, P < 0.001) was significantly greater than that with candesartan (10.4 mm Hg, 7.7 mm Hg to 13.1 mm Hg, P < 0.001) or lisinopril (mean 10.7 mm Hg. 8.0 nun Hg to 13.5 mm Hg, P < 0.001). Furtherm ore, the reduction in urinary albumin:creatinine ratio with combination tre atment (50%, 36% to 61%, P<0.001) was greater than with candesartan (24%, 0 % to 43%, P = 0.05) and lisinopril (39%, 20% to 54%, P < 0.001). All treatm ents were generally well tolerated. Conclusion Candesartan 16 mg once daily is as effective as lisinopril 20 mg once daily in reducing blood pressure and microalbuminuria in hypertensive patients with type 2 diabetes. Combination treatment is well tolerated and more effective in reducing blood pressure.