Synthesis and in vitro cytotoxic evaluation of N-substituted benzo[5,6]cyclohepta[b]indoles

Authors
Joseph, B Alagille, D Merour, JY Leonce, S
Citation
B. Joseph et al., Synthesis and in vitro cytotoxic evaluation of N-substituted benzo[5,6]cyclohepta[b]indoles, CHEM PHARM, 48(12), 2000, pp. 1872-1876
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
48
Issue
12
Year of publication
2000
Pages
1872 - 1876
Database
ISI
SICI code
0009-2363(200012)48:12<1872:SAIVCE>2.0.ZU;2-9
Abstract
A new series of N-substituted benzo[5,6]cyclohepta[b]indole derivatives wer e synthesised and evaluated for in vitro cytotoxic activities against L1210 murine leukemia and HT29 cell lines. Among them, several compounds showed potent antitumor activity and blocked cell cycle progression of L1210 cells in G(2)+M phase.