We describe the development of transnasal endoscopic approaches to the cran
ial base in an interdisciplinary series of 103 patients, including 13 in th
e pediatric age group. Our aim was to define, with the aid of different cas
e reports, the possibilities of endoscopic techniques in tumor resection, f
istula repair, the treatment of mucoceles and meningoceles, and of combined
intracranial and endoscopic approaches. The advantages of these minimally
invasive approaches are panoramic visualization, rapidity and reduction of
the cosmetic and functional disabilities in comparison with other conventio
nal approaches, and a better capacity for identifying and developing key la
ndmarks for surgery. On the other hand, endoscopic surgery requires an exsa
nguine operation field, technical improvements in instruments, and specific
skills. Interdisciplinary collaboration in endoscopic approaches has prove
d useful in integrating experiences without overlap between fields, and in
broadening possibilities: in our opinion endoscopic approaches will certain
ly be important in the future of cranial base surgery.