Expression of CDKI p27(Kip1) trophoblastic neoplasm

Objective To evaluate the role of p27(Kip1) in tumorigenesis and the develo pment of trophoblastic cell disease. Methods Using immunohistochemistry, the expression of p27-protein was inves tgated in 10 normal chorionic villi in the first trimester of pregnancy, 15 complete hydatidiform moles (HM), 7 invasive moles (IM) and 7 choriocarcin omas (CC). Results in art cases, immunohistochemical staining localized p27-protein in the plasma. Decreased expression of p27(Kip1) was observed in malignant tr ophoblastic neoplasms with a positive rate of 21.43%, which is significantl y less than that in normal chorionic villi (80%) and in complete HM (73.33% ) (P < 0.05). The positive rate of p27(Kip1) in those complete HM with larg e uterine size for gestational age was tower than that in those with normal or small uterus (42.86% vs 100%, P<0.05). Conclusion p27(Kip1) may be involved in the tumorigenesis of gestational tr ophoblastic neoplasm as a negative regulator of the cell cycle. The express ion level of p27(Kip1) in trophoblastic: cells may be a prognostic factor f or complete HM.