Decline in antibiotic enzyme activity of neutrophils is a prognostic factor for infections in patients with myelodysplastic syndrome

Authors
Ito, Y Kawanishi, Y Shoji, N Ohyashiki, K
Citation
Y. Ito et al., Decline in antibiotic enzyme activity of neutrophils is a prognostic factor for infections in patients with myelodysplastic syndrome, CLIN INF D, 31(5), 2000, pp. 1292-1295
Citations number
20
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
CLINICAL INFECTIOUS DISEASES
ISSN journal
10584838 → ACNP
Volume
31
Issue
5
Year of publication
2000
Pages
1292 - 1295
Database
ISI
SICI code
1058-4838(200011)31:5<1292:DIAEAO>2.0.ZU;2-C
Abstract
We used how cytometry to measure the activities of cathepsin G and elastase . The activity of elastase in neutrophils from patients with myelodysplasti c syndrome (MDS) was significantly lower than that in neutrophils from the control group (P < .001). Patients with low elastase activity were signific antly susceptible to infection (P < .05). Our study suggests that analyzing antibacterial enzymes is useful in evaluating the prognosis of patients wi th MDS.