Women with a history of gestational diabetes of European and South Asian origin are shorter than women with normal glucose tolerance in pregnancy

Aims It has been reported that short individuals are more likely to have ab normalities of glucose homeostasis. The aim of this study was to examine th e relationship between adult height and gestational diabetes mellitus (GDM) , taking into account possible artefactual or confounding explanations. Methods Three hundred and forty-six women with previous GDM (169 European, 102 South Asian, 75 Afro-Caribbean) and 470 control women with no previous history of GDM (282 European, 94 South Asian and 94 Afro-Caribbean) were st udied. Post-partum glucose status and height were measured. Results European and South Asian women with previous GDM were shorter than control women from the same ethnic groups (European: (mean +/- sd) 162.9 +/ - 6.1 vs. 165.3 +/- 6.8 cm, P < 0.0001; South Asian: 155.2 +/- 5.4 vs. 158. 2 +/- 6.3 cm, P = 0.003, adjusted for age). A similar, but non-significant trend was observed among Afro-Caribbean women (162.2 +/- 6.2 vs. 163.7 +/- 6.1 cm, P = 0.1). Similar, significant height differences were observed in Europeans and South Asians when analysis was restricted to those GDM women who had received insulin during pregnancy. There was no association between height and glucose tolerance post-partum within the GDM group. Conclusions European and South Asian women with previous GDM are shorter th an control women from the same ethnic groups. The data demonstrate that thi s is unlikely to be an artefact resulting from the use of an fixed 75 g loa d in women of differing sizes, and suggest that there are likely to be comm on pathophysiological mechanisms underlying GDM and the determination of fi nal adult height.